Methylfolate and MTHFR

Dr. Benjamin Lynch found that a portion of his MTHFR patients developed anxiety, irritability, and other symptoms after taking methylfolate. He found that 50 to 100 mg of niacin ameliorated the effects.¹
We also found that niacin (niacinamide) did, in fact, lessen anxiety and irritability when it developed in a small number of individuals who experienced these same symptoms after taking Hardy Nutritionals^® Daily Essential Nutrients (DEN). DEN contains methyfolate, methylcobalamin, and choline, which are all methyl donors. Several of these individuals had previously tested positive for MTHFR polymorphisms.

1. http://mthfr.net/methylfolate-side-effects/2012/03/01/ Accessed 13 April 2018.