Appendix H Biotin Interference in Diagnostic Tests

Appendix H Biotin Interference in Diagnostic Tests

Biotin Interference in Diagnostic Tests

 

References

FDA (Biotin) Safety Communication 2019

National Institutes of Health. Biotin fact sheet for consumers

Roche Diagnostics. Biotin facts

The University of Iowa, Department of Pathology, Laboratory Services Handbook: Serum folate

 

Test List

User's Guide Name

Test Mnemonic

Test Order Number

ACTH by Immunohistochemistry

ACTH IHC

2003427

Adrenocorticotropic Hormone

ACTH

70010

Adrenocorticotropic Hormone Stimulation, 30 Minutes

CORTISOL30

70032

Adrenocorticotropic Hormone, IVC1

ACTH IVC1

70279

Adrenocorticotropic Hormone, LP1

ACTH LP1

70300

Adrenocorticotropic Hormone, RP1

ACTH RP1

70311

Alpha-1-Antichymotrypsin (A1ACT) by Immunohistochemistry

A1 ACT IHC

2003418

Alpha-1-Antitrypsin (AAT) by Immunohistochemistry

A1 AT IHC

2003424

Alpha-1-Fetoprotein (AFP) by Immunohistochemistry

AFP IHC

2003436

Amphiphysin Antibody, IgG

AMPHIPHYS

2008893

Anti-Human Epithelial Antigen, Ber-EP4 by Immunohistochemistry

BEREP4 IHC

2003463

Aquaporin-4 Receptor Antibody

AQP4

2003036

Aquaporin-4 Receptor Antibody by ELISA with Reflex to Aquaporin-4 Receptor Antibody, IgG by IFA

AQP4 R

2013327

Autoimmune Liver Assessment w/ Reflx

AUTO LIVER

2010850

Autoimmune Neuromuscular Junction Reflexive Panel

MUWA R PAN

2005640

Beta-hCG, Quantitative (Tumor Marker)

BHCG TM

70029

Beta-hCG, Quantitative (Tumor Marker), CSF

BHCG CSF

20730

Breast 2 (GCDFP-15) by Immunohistochemistry

BRST2 IHC

2003472

Breast Carcinoma b72.3 by Immunohistochemistry

B72.3 IHC

2003445

C1-Esterase Inhibitor Functional

C1 INH F

50141

C-1-Esterase Inhibitor Panel

C1 INH PAN

50139

C4D by Immunohistochemistry

C4D IHC

2003475

Cancer Antigen 125

CA125

80462

Cancer Antigen-Breast (CA 15-3)

CA-BREAST

80464

Cancer Antigen-GI (CA 19-9)

CA-GI

80461

Cancer Antigen-GI (CA 19-9), Body Fluid

CA-GI FL

20746

Carcinoembryonic Antigen

CEA

80080

Carcinoembryonic Antigen, Fluid

CEA FL

20742

Carcinoembryonic Antigen, Polyclonal (CEA P) by Immunohistochemistry

CEA P IHC

2003827

CD123 by Immunohistochemistry

CD123 IHC

2003809

CD1a by Immunohistochemistry

CD1A IHC

2003502

CD21 (Dendritic Cell) by Immunohistochemistry

CD21 IHC

2003535

CD23 by Immunohistochemistry

CD23 IHC

2003541

CD31 by Immunohistochemistry

CD31 IHC

2003550

CD34, QBEnd/10 by Immunohistochemistry

CD34 IHC

2003556

CD35 by Immunohistochemistry

CD35 IHC

2003559

CD4 by Immunohistochemistry

CD4 IHC

2003511

CD42b by Immunohistochemistry (Temporary Referral as of 08/22/2017)

CD42b IHC

2003565

CD43, L60 (Leu 22) by Immunohistochemistry

CD43 IHC

2003568

CD61 (Platelet Glycoprotein IIIA) by Immunohistochemistry

CD61 IHC

2003595

CD79A by Immunohistochemistry

CD79A IHC

2003800

Collagen IV by Immunohistochemistry

COLL 4 IHC

2003839

Cotinine Screen, Urine

COTININE

2007081

C-Telopeptide, Beta-Cross-Linked, Serum

CTX

70416

CYFRA 21-1 (Cytokeratin 19 Fragment), Serum

CYFRA

81344

Cytokeratin 20 (CK 20) by Immunohistochemistry

CYTO20 IHC

2003848

Cytokeratin 8,18 Low Molecular Weight (CAM 5.2) by Immunohistochemistry

CAM5.2 IHC

2003493

Cytokine Panel

CYT 12 SE

51394

Cytokine Panel, Monokines

CYT MON SE

51524

Cytokine Panel, TH1

CYT TH1 SE

51408

Cytokine Panel, TH2

CYT TH2 SE

51518

Cytokine Production by Mononuclear Cells in Response to Antigen and Mitogen Stimulation

CYT AM

2013111

Dehydroepiandrosterone Sulfate, Serum

DHEAS

70040

E-Cadherin by Immunohistochemistry

ECADH IHC

2003869

Epithelial Membrane Antigen (EMA) by Immunohistochemistry

EMA IHC

2003872

Epstein-Barr Virus (EBV) by in situ Hybridization, Paraffin

EBV ISH

2002902

Estrogen Receptor (ER) by Immunohistochemistry

ER IHC

2004516

Ewing Sarcoma (O13) by Immunohistochemistry

O13 IHC

2004055

Fetal Fibronectin

FFN

82024

Fibrillarin (U3 RNP) Antibody, IgG

U3 FIB

2012173

FIBRINOGEN by IF Technical Only (Bill Only, for Internal Use Only)

FIBR IFT

2005397

Follicle Stimulating Hormone, Serum

FSH

70055

Gastrin

GAST

70075

Gastrin by Immunohistochemistry

GASTRI IHC

2003896

Gastrin, 1 Minute

GAST 1

2012636

Gastrin, 10 Minute

GAST 10

2012734

Gastrin, 2 Minute

GAST 2

2012638

Gastrin, 30 Minute

GAST 30

2012736

Gastrin, 5 Minute

GAST 5

2012732

Gastrin, Baseline

GAST BASE

2012738

Glial Fibrillary Acidic Protein (GFAP) by Immunohistochemistry

GFAP IHC

2003899

Glycophorin A by Immunohistochemistry

GLYC A IHC

2003908

Granzyme B by Immunohistochemistry

GRANZB IHC

2007173

Hairy Cell Leukemia, DBA.44 by Immunohistochemistry

DBA 44 IHC

2003860

Hepatitis A Virus Antibodies (Total)

HAVAB

20591

Hepatitis A Virus Antibody, IgM

HAVABM

20093

Hepatitis A Virus Panel

HEP A PAN

20597

Hepatitis B Virus (HBV) Perinatal Exposure Follow-up by CIA, Panel

HBV PAN PN

2014285

Hepatitis B Virus Core Antibodies (Total)

HBCAB

20091

Hepatitis B Virus Core Antibody, IgM

HBCABM

20092

Hepatitis B Virus Panel, Chronic with Reflex to HBsAg Confirmation

HEPCHRONIC

20454

Hepatitis B Virus Surface Antibody

HBSAB

20090

Hepatitis B Virus Surface Antigen Confirmation, Prenatal

HBSAGCONPN

2007575

Hepatitis B Virus Surface Antigen with Reflex to Confirmation

HBSAG

20089

Hepatitis B Virus Surface Antigen with Reflex to Confirmation, Prenatal

HBSAG PN

2007573

Hepatitis B Virus Surface Antigen, Confirmation

HBSAG CONF

20128

Hepatitis C Virus Antibody by CIA

HCV AB

2002483

Hepatitis C Virus Antibody by CIA with Reflex to HCV by Quantitative PCR

HCV AB QR

2010784

Hepatitis Panel, Acute with Reflex to HBsAg Confirmation

HEP ACUTE

20457

Hepatocyte Specific Antigen (HSA) by Immunohistochemistry

HEP SA IHC

2003923

Histoplasma Antigen by EIA, Serum

HISTOAG S

92522

Histoplasma Galactomannan Antigen Quantitative by EIA, Urine

HISTOGM U

2009418

Human Chorionic Gonadotropin (Beta-hCG) by Immunohistochemistry

HCG IHC

2003920

Human Epididymis Protein 4 (HE4)

HE4

2003020

Human Immunodeficiency Virus (HIV) Combo Antigen/Antibody (HIV-1/O/2) by CIA with Reflex to HIV-1/HIV-2 Antibody Differentiation, Supplemental

HIVAGABGE

2013333

Human Immunodeficiency Virus (HIV) Combo Antigen/Antibody (HIV-1/O/2) by CIA, Reflexive Panel

HIV PANEL

2012674

Human Immunodeficiency Virus (HIV) Combo Antigen/Antibody (HIV-1/O/2) by CIA, with Reflex to HIV-1 Antibody Confirmation by Western Blot

HIV AGAB

2006526

Human Immunodeficiency Virus Type 1 (HIV-1) Antibody by CIA with Reflex to HIV-1 Antibody Confirmation by Western Blot

HIV 1 SCRN

2005375

Human Immunodeficiency Virus Types 1 and 2 (HIV-1, HIV-2) Antibodies by CIA with Reflex to HIV-1 Antibody Confirmation by Western Blot

HIV1,2 SCR

2005377

Human Papillomavirus (HPV) Low Risk by in situ Hybridization, Paraffin

HPVLOW ISH

2002896

Human Papillomavirus (HPV), High Risk by in situ Hybridization, Paraffin

HPVHI ISH

2002899

Human Placental Lactogen (HPL) by Immunohistochemistry

HPL IHC

2003938

Immunoglobulin A (IgA) by Immunohistochemistry

IGA IHC

2003957

Immunoglobulin D (IgD) by Immunohistochemistry

IGD IHC

2003960

Immunoglobulin M (IgM) by Immunohistochemistry

IGM IHC

2003966

Influenza A Virus H1/H3 Subtype by PCR with Reflex to H1N1 (2009) Oseltamivir Resistance by Sequencing

FLUTYPE RE

2008788

Inhibin by Immunohistochemistry

INHIBI IHC

2003969

Interferon gamma

IFNG DO

51531

Interleukin 1 beta

IL1B DO

51536

Interleukin 10

IL10 DO

51534

Interleukin 12

IL12 DO

51530

Interleukin 13

IL13 DO

51535

Interleukin 17

IL17

2013115

Interleukin 2

IL2 DO

51588

Interleukin 2 Receptor (CD25), Soluble

IL2R DO

51529

Interleukin 4

IL4 DO

51532

Interleukin 5

IL5 DO

51533

Interleukin 6

IL6 DO

51537

Interleukin 8

IL8 DO

51538

Kappa Light Chains by Immunohistochemistry

KAPPA IHC

2003981

Kappa/Lambda Light Chain Panel by in situ Hybridization, Paraffin

K/L ISH

2002888

Keratin 903 (K903) High Molecular Weight by Immunohistochemistry

K903 IHC

2003978

Ki-67, MIB-1, by Immunohistochemistry

MIB1 IHC

2004519

Lambda Light Chains by Immunohistochemistry

LAMBDA IHC

2003984

Liver Cytosolic Antigen Type 1 (LC-1) Antibody, IgG

LC-1

2010711

Luteinizing Hormone and Follicle Stimulating Hormone

LH/FSH

70193

Luteinizing Hormone, Serum

LH

70093

Lysozyme (Muramidase) by Immunohistochemistry

LYSOZY IHC

2003990

Mannose Binding Lectin

MBL

51692

Mast Cell Tryptase by Immunohistochemistry

MASTCT IHC

2003993

Muscle-Specific Actin (MSA) by Immunohistochemistry

MUSA IHC

2004011

Myeloperoxidase (MPO) by Immunohistochemistry

MYELOP IHC

2004014

Myoglobin by Immunohistochemistry

MYOGL IHC

2004031

Myoglobin, Serum

MYOG-S

20224

Myoglobin, Urine

MYOG-U

20223

Myosin by Immunohistochemistry

MYOSIN IHC

2004034

Neurofilament by Immunohistochemistry

NEUROF IHC

2004049

Neuron Specific Enolase

NSE

98198

Neuron Specific Enolase, CSF

NSE CSF

81226

Neuron Specific Enolase, Polyclonal (NSE P) by Immunohistochemistry

NSE IHC

2004052

Neuronal Abs (Hu, Ri, Yo, Amphiphysin)

NEURONAL

51090

Neuronal Nuclei (NeuN) by Immunohistochemistry

NEUN IHC

2004046

New York Human Immunodeficiency Virus (HIV) Combo Antigen/Antibody (HIV-1/O/2), Reflexive Panel

NY HIV PAN

2014211

Osteocalcin by Electrochemiluminescent Immunoassay

OSTEO NMID

20728

p21 (Waf1/Cip 1) by Immunohistochemistry

P21 IHC

2004067

p53 by Immunohistochemistry

P53 IHC

2004522

Pan Cytokeratin (AE1,3) by Immunohistochemistry

AE1,3 IHC

2003433

Pancreatic Elastase, Fecal by ELISA

PAN-ELAST

80526

Paraneoplastic Reflexive Panel

PNS PAN

2013955

Parathyroid Hormone, Fine Needle Aspiration (FNA)

PTH FNA

2001491

Parathyroid Hormone, Intact

PTH-INT

70346

Parathyroid Hormone, Intact with Calcium

PTHI

70172

PAX8 by Immunohistochemistry

PAX8 IHC

2010787

PD-1 by Immunohistochemistry

PD1 IHC

2004085

Placental Alkaline Phosphatase (PLAP) by Immunohistochemistry

PLAP IHC

2004097

PM/Scl-100 Antibody, IgG by Immunoblot

PM/SCL

2003040

Prenatal Reflexive Panel

PRENATAL A

95044

proBrain Natriuretic Peptide, NT

PRO BNP

50083

Progesterone Receptor (PR) by Immunohistochemistry

PR IHC

2004525

Prolactin by Immunohistochemistry

PROLAC IHC

2004109

Prostate Specific Antigen, Free Percentage (Includes Free PSA and Total PSA)

PSA FP

80206

Prostate Specific Antigen, Total

PSA

70121

Prostate Specific Antigen, Total - Medicare Screening

PSA SCN

70234

Prostate Specific Antigen, Total with Reflex to Free PSA (Includes Free Percentage)

TPSAR

80264

Prostate Specific Antigen, Ultrasensitive

PSA ULTRA

98581

Prostatic Acid Phosphatase (PAP) by Immunohistochemistry

PAP IHC

2004079

Reflexed to Free PSA (Includes Free Percentage)

BILL PSAFR

50338

Risk of Ovarian Malignancy Algorithm

ROMA

2012618

S100B CSF

S100B CSF

2013358

S-100B Protein, Serum

S 100B

2001766

Sex Hormone Binding Globulin

SHBG

99375

Smooth Muscle Actin (SMA) by Immunohistochemistry

SMA IHC

2004130

Surgical Pathology Tissue

SP REQUEST

8090010

Systemic Sclerosis Comprehensive Panel

SCL COMP

2013325

T3 Uptake

T3 UP

70135

T-cell Intracytoplasmic Antigen (TIA-1) by Immunohistochemistry

TIA1 IHC

2004148

TdT by Immunohistochemistry

TDT IHC

2004142

Testosterone Free, Adult Male

FREE T2

70111

Testosterone, Adult Male

TESTOS

70130

Testosterone, Bioavailable and Sex Hormone Binding Globulin (Includes Total Testosterone), Adult Male

BIO T

70102

Testosterone, Free and Total (Includes Sex Hormone Binding Globulin), Adult Male

FREE T

70109

Thyroglobulin Antibody

ATHYG

50105

Thyroid Antibodies

THYRO

50645

Thyroid Peroxidase (TPO) Antibody

AMICR

50075

Thyroid Stimulating Hormone

TSH

70145

Thyroid Stimulating Hormone Receptor Antibody (TRAb)

TR AB

2002734

Thyroid Transcription Factor (TTF-1) by Immunohistochemistry

TTF1 IHC

2004166

Thyroxine

T4

70140

Thyroxine, Free (Free T4)

FT4

70138

Toll-Like Receptor Function

TLR

51589

Toxoplasma gondii by Immunohistochemistry (Temporary Referral as of 08/22/2017)

TOXOPL IHC

2004157

Transforming Growth Factor beta, Plasma

TGFB PLA

51690

Transforming Growth Factor beta, Serum

TGFB SER

51694

Triiodothyronine, Free (Free T3)

FT3

70133

Triiodothyronine, Total (Total T3)

T3 TOTAL

70474

Troponin T (cTnT) 5th Generation

CTNT

3001831

Tumor Necrosis Factor - alpha

TNFA DO

51539

Vitamin D, 1, 25-Dihydroxy

VIT D 1,25

80385